HCID 16120412, compound → HCID 16120413, compound

HRID 1792037Notes

Reaction equation

HRID 1792037 reaction equation
C([N:8]1[C:16]2[C:15](=[O:17])[N:14]([CH2:18][O:19][C:20](=[O:25])[C:21]([CH3:24])([CH3:23])[CH3:22])[C:13](=[O:26])[N:12]([CH3:27])[C:11]=2[N:10]=[CH:9]1)C1C=CC=CC=1>C(O)(=O)C.[Pd]>[CH3:27][N:12]1[C:11]2[N:10]=[CH:9][NH:8][C:16]=2[C:15](=[O:17])[N:14]([CH2:18][O:19][C:20](=[O:25])[C:21]([CH3:22])([CH3:23])[CH3:24])[C:13]1=[O:26]

Participants

4

Reactant 1

HCID 16120412HCID 16120412, compound

Product 1

HCID 16120413HCID 16120413, compoundYield 92.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

2,2-Dimethylpropionic acid 7-benzyl-3-methyl-2,6-dioxo-2,3,6,7-tetrahydropurin-1-ylmethyl ester (4.26 g) was dissolved in acetic acid (100 ml), and 10% palladium on carbon (1.5 g) was added thereto. The reaction mixture was stirred under hydrogen atmosphere at room temperature overnight, filtered through Celite, and the filtrate was concentrated to give 2.98 g of the title compound.

Workup

  1. filtrationfiltered through Celite
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-0ccd82a36e79434a81b3766ff31c1625
Source dataset
uspto-grants-2006_07
Patent number
US07074798B2

Reaction notes

Loading…