Trifluoroacetic acid → HCID 22029680, compound

HRID 1792040Notes

Reaction equation

HRID 1792040 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:22]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[Cl:29])[C:21]3[C:20](=[O:30])[NH:19][C:18](=[O:31])[N:17]([CH3:32])[C:16]=3[N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[F:33][C:34]([F:39])([F:38])[C:35]([OH:37])=[O:36]>>[F:33][C:34]([F:39])([F:38])[C:35]([OH:37])=[O:36].[Cl:29][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=1[N:22]1[C:21]2[C:20](=[O:30])[NH:19][C:18](=[O:31])[N:17]([CH3:32])[C:16]=2[N:15]=[C:14]1[N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 23081901HCID 23081901, compound

Product 1

HCID 22029680HCID 22029680, compound

Procedure

4-[7-(2-Chlorophenyl)-3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]piperazine-1-carboxylic acid tert-butyl ester (8 mg) was dissolved in trifluoroacetic acid, and the solution was concentrated. The residue was purified by reversed phase high performance liquid chromatography to give 3.86 mg of the title compound.

Workup

  1. concentrationthe solution was concentrated
  2. customThe residue was purified by reversed phase high performance liquid chromatography

Sources & evidence

ORD record
ord-75df780a0b9744e38a7dfb977aa4d112
Source dataset
uspto-grants-2006_07
Patent number
US07074798B2

Reaction notes

Loading…