Trifluoroacetic acid → HCID 69542391, compound

HRID 1792049Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:22]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[Cl:29])[C:21]3[C:20](=[O:30])[N:19]([CH3:31])[C:18](=[O:32])[N:17]([CH2:33][C:34]([O:36][CH3:37])=[O:35])[C:16]=3[N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[F:38][C:39]([F:44])([F:43])[C:40]([OH:42])=[O:41]>>[F:38][C:39]([F:44])([F:43])[C:40]([OH:42])=[O:41].[CH3:37][O:36][C:34](=[O:35])[CH2:33][N:17]1[C:16]2[N:15]=[C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[N:22]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[Cl:29])[C:21]=2[C:20](=[O:30])[N:19]([CH3:31])[C:18]1=[O:32]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 23536949HCID 23536949, compound

Product 1

HCID 69542391HCID 69542391, compound

Procedure

4-[7-(2-Chlorophenyl)-3-methoxycarbonylmethyl-1-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]piperazine-1-carboxylic acid tert-butyl ester (26 mg) was dissolved in trifluoroacetic acid, and concentrated. The residue was purified by reversed phase high performance liquid chromatography to give 8.09 mg of the title compound.

Workup

concentrationconcentrated
customThe residue was purified by reversed phase high performance liquid chromatography

Sources & evidence

ORD record: ord-b986c9c794964f64b10a4786497adfc1
Source dataset: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07074798B2

Reaction notes

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