Hydrochloric Acid → HCID 86591948, compound

HRID 1792050Notes

Reaction equation

HRID 1792050 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:22]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[Cl:29])[C:21]3[C:20](=[O:30])[N:19]([CH3:31])[C:18](=[O:32])[N:17]([CH2:33][C:34](OC)=[O:35])[C:16]=3[N:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].Cl>CO>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:22]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[Cl:29])[C:21]3[C:20](=[O:30])[N:19]([CH3:31])[C:18](=[O:32])[N:17]([CH:33]=[C:34]=[O:35])[C:16]=3[N:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 23536949HCID 23536949, compound

Product 1

HCID 86591948HCID 86591948, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-[7-(2-Chlorophenyl)-3-methoxycarbonylmethyl-1-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]piperazine-1-carboxylic acid tert-butyl ester (87 mg) was dissolved in methanol (2 ml), and 5N aqueous sodium hydroxide solution (0.2 ml) was added to the solution. Then, the mixture was stirred at room temperature for 2 hours. The mixture was neutralized with 1N hydrochloric acid, and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and filtered. The solvent was removed by distillation to give the title compound.

Workup

  1. extractionextracted with ethyl acetate
  2. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  3. filtrationfiltered
  4. customThe solvent was removed by distillation

Sources & evidence

ORD record
ord-d62a16b46a5b436791db6b90bf932770
Source dataset
uspto-grants-2006_07
Patent number
US07074798B2

Reaction notes

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