Trifluoroacetic acid → HCID 69542313, compound

HRID 1792051Notes

Reaction equation

HRID 1792051 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:22]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[Cl:29])[C:21]3[C:20](=[O:30])[N:19]([CH3:31])[C:18](=[O:32])[N:17]([CH2:33][C:34]([OH:36])=[O:35])[C:16]=3[N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[F:37][C:38]([F:43])([F:42])[C:39]([OH:41])=[O:40]>>[F:37][C:38]([F:43])([F:42])[C:39]([OH:41])=[O:40].[Cl:29][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=1[N:22]1[C:21]2[C:20](=[O:30])[N:19]([CH3:31])[C:18](=[O:32])[N:17]([CH2:33][C:34]([OH:36])=[O:35])[C:16]=2[N:15]=[C:14]1[N:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 23081942HCID 23081942, compound

Product 1

HCID 69542313HCID 69542313, compound

Procedure

4-[7-(2-Chlorophenyl)-3-carboxymethyl-1-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]piperazine-1-carboxylic acid tert-butyl ester (26 mg) was dissolved in trifluoroacetic acid, and was concentrated. The residue was purified by reversed phase high performance liquid chromatography to give 10.73 mg of the title compound.

Workup

  1. concentrationwas concentrated
  2. customThe residue was purified by reversed phase high performance liquid chromatography

Sources & evidence

ORD record
ord-4f6ded5d4a094ef798bf89f556b1e2b4
Source dataset
uspto-grants-2006_07
Patent number
US07074798B2

Reaction notes

Loading…