tert-Butyl piperazine-1-carboxylate → HCID 23536958, compound

HRID 1792073Notes

Reaction equation

HRID 1792073 reaction equation
[CH2:1]([O:3][C:4](=[O:30])[CH2:5][N:6]1[C:14]2[N:13]=[C:12](Cl)[N:11]([CH2:16][C:17]#[C:18][CH3:19])[C:10]=2[C:9](=[O:20])[N:8]([CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:7]1=[O:29])[CH3:2].[C:31]([O:35][C:36]([N:38]1[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]1)=[O:37])([CH3:34])([CH3:33])[CH3:32]>>[C:31]([O:35][C:36]([N:38]1[CH2:43][CH2:42][N:41]([C:12]2[N:11]([CH2:16][C:17]#[C:18][CH3:19])[C:10]3[C:9](=[O:20])[N:8]([CH2:21][CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[C:7](=[O:29])[N:6]([CH2:5][C:4]([O:3][CH2:1][CH3:2])=[O:30])[C:14]=3[N:13]=2)[CH2:40][CH2:39]1)=[O:37])([CH3:34])([CH3:32])[CH3:33]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 23536903HCID 23536903, compound

Product 1

HCID 23536958HCID 23536958, compoundYield 86.9%

Conditions

Temperature
150 °C

Procedure

A mixture of [7-(2-butynyl)-8-chloro-1-(2-phenylethyl)-2,6-dioxo-1,2,6,7-tetrahydropurin-3-yl]acetic acid ethyl ester (273 mg) and piperazine-1-carboxylic acid tert-butyl ester (360 mg) was heated in an oil bath of 150° C. for 30 minutes. The reaction mixture was purified by silica gel column chromatography using 20–30% ethyl acetate/hexane to give 320 mg of the title compound.

Workup

  1. customThe reaction mixture was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-2d0a2336539b45ccbf1ab591a226384a
Source dataset
uspto-grants-2006_07
Patent number
US07074798B2

Reaction notes

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