tert-Butyl piperazine-1-carboxylate → HCID 23536958, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of [7-(2-butynyl)-8-chloro-1-(2-phenylethyl)-2,6-dioxo-1,2,6,7-tetrahydropurin-3-yl]acetic acid ethyl ester (273 mg) and piperazine-1-carboxylic acid tert-butyl ester (360 mg) was heated in an oil bath of 150° C. for 30 minutes. The reaction mixture was purified by silica gel column chromatography using 20–30% ethyl acetate/hexane to give 320 mg of the title compound.

Provenance & Evidence