Trifluoroacetic acid → HCID 11333276, compound

HRID 1792157Notes

Reaction equation

HRID 1792157 reaction equation
C(OC([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([S:17]([CH3:20])(=[O:19])=[O:18])[CH:15]=2)[CH:10]=[C:9]1[CH3:21])=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:20][S:17]([C:14]1[CH:15]=[C:16]2[C:11]([CH:10]=[C:9]([CH3:21])[NH:8]2)=[CH:12][CH:13]=1)(=[O:19])=[O:18]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69312246HCID 69312246, compound

Product 1

HCID 11333276HCID 11333276, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The above product of step 2 was dissolved in 100 mL methylene chloride and treated with 12 mL TFA. After stirring overnight, the volatiles were removed and the product crystallized from 10:1 methylene chloride/MeOH. In this way 8.0 g of 6-methanesulfonyl-2-methyl-1H-indole was obtained.

Workup

  1. customthe volatiles were removed
  2. customthe product crystallized from 10:1 methylene chloride/MeOH

Sources & evidence

ORD record
ord-a767b45ee400491aa014c4ceb48dbe06
Source dataset
uspto-grants-2006_07
Patent number
US07074939B2

Reaction notes

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