反应详情

Heat a solution of 4-chloro-2-methyl-9-(2,4,6-trimethylphenyl)pyridino[2,3-b]-indolizine (0.35 g, 1.04 mmol), and ethylene diamine (0.32 g, 1.04 mmol) in dry NMP (3 mL) at 100° C. for 5 h. Pour the cooled mixture onto water (30 mL) and extract twice with EtOAc (30 mL). Wash the combined extract with brine (30 mL), dry, and evaporate in vacuo. Purify by preparative TLC (20% MeOH in CH2Cl2 with 1% ammonium hydroxide) to obtain the title compound as a colorless oil.

1. additionPour the cooled mixture onto water (30 mL)
2. extractionextract twice with EtOAc (30 mL)
3. washWash the
4. extractioncombined extract with brine (30 mL)
5. customdry
6. customevaporate in vacuo
7. customPurify by preparative TLC (20% MeOH in CH2Cl2 with 1% ammonium hydroxide)