反应详情

To a solution of 7-methoxy-3-(4-methoxyphenyl)-3-methylthiochroman-4-one (2.27 g, 7.22 mmol) in acetic acid (75 ml) was added 48% aqueous HBr solution (75 mg), which was then heated under reflux for 1 day. The reaction mixture was extracted with diethyl ether. The organic layer was washed with saturated sodium bicarbonate solution and saturated saline solution, dried over anhydrous magnesium sulfate, and concentrated. Then, the residue was subjected to flash chromatography on silica gel (n-hexane:ethyl acetate=7:3 and 1:1) to give the title compound (1.92 g, yield 92%).

1. temperaturewas then heated
2. temperatureunder reflux for 1 day
3. extractionThe reaction mixture was extracted with diethyl ether
4. washThe organic layer was washed with saturated sodium bicarbonate solution and saturated saline solution
5. dry with materialdried over anhydrous magnesium sulfate
6. concentrationconcentrated