HRID1792362

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COCOc1ccc(C2(C)COc3cc(OCOC)ccc3C2(O)C#CCCO[Si](C)(C)C(C)(C)C)cc1

HCID22033420

未命名化合物

PRODUCTS

生成物

结构：COCOc1ccc(C2(C)COc3cc(OCOC)ccc3C2CCCCO[Si](C)(C)C(C)(C)C)cc1

HCID22033330

未命名化合物

收率 44%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

4-[4-(t-butyl dimethylsilyloxy)-1-butynyl]4-hydroxy-7-methoxymethoxy-3-(4-(methoxymethoxy)phenyl)-3-methylchroman (1.6 g, 2.95 mmol) was dissolved in ethyl acetate (30 ml), and then 10% Pd/C (0.6 g) was added thereto. The reaction suspension was stirred under hydrogen for 1 hour, filtered, and concentrated. The residue was subjected to silica gel column chromatography (n-hexane:ethyl acetate=20:1) to give the title compound (680 mg, yield 44%) as a colorless oil.

WORKUP

后处理

filtrationfiltered
concentrationconcentrated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a7b88fd5bae64d6f9748f798e29b7a11
来源数据集: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07074819B2
来源说明: uspto-grants-2006_07

反应 SMILES

[Si:1]([O:8][CH2:9][CH2:10][C:11]#[C:12][C:13]1(O)[C:22]2[C:17](=[CH:18][C:19]([O:23][CH2:24][O:25][CH3:26])=[CH:20][CH:21]=2)[O:16][CH2:15][C:14]1([C:28]1[CH:33]=[CH:32][C:31]([O:34][CH2:35][O:36][CH3:37])=[CH:30][CH:29]=1)[CH3:27])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]>C(OCC)(=O)C.[Pd]>[Si:1]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH:13]1[C:22]2[C:17](=[CH:18][C:19]([O:23][CH2:24][O:25][CH3:26])=[CH:20][CH:21]=2)[O:16][CH2:15][C:14]1([C:28]1[CH:29]=[CH:30][C:31]([O:34][CH2:35][O:36][CH3:37])=[CH:32][CH:33]=1)[CH3:27])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:2])[CH3:3]