1-(2-Pyridyl)piperazine → 6-Bromo-4-[4-(2-pyridyl)piperazin-1-yl]quinoline

HRID 1792435Notes

Reaction equation

HRID 1792435 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[C:5]2Cl.[N:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[C:5]2[N:22]1[CH2:23][CH2:24][N:19]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][N:13]=2)[CH2:20][CH2:21]1

Participants

3

Reactant 2

HCID 944591-(2-Pyridyl)piperazineHCID 51395376-Bromo-4-chloroquinoline

Product 1

HCID 220313186-Bromo-4-[4-(2-pyridyl)piperazin-1-yl]quinoline

Procedure

291 mg 6-bromo-4-chloroquinoline and 0.91 mL 4-(2-pyridyl)piperazine were reacted by the same method as in Production Example 74 to give 373 mg of the title compound as a colorless oil.

Sources & evidence

ORD record
ord-9f5c47e6abf24ea29759758b6122ce6b
Source dataset
uspto-grants-2006_07
Patent number
US07074801B1

Reaction notes

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