6-Bromo-4-chloroquinoline → 6-Bromo-4-[(3R)-3-methoxytetrahydro-1H-1-pyrrolyl]quinoline

HRID 1792439Notes

Reaction equation

HRID 1792439 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[C:5]2Cl.Cl.[CH3:14][O:15][C@@H:16]1[CH2:20][CH2:19][NH:18][CH2:17]1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[C:5]2[N:18]1[CH2:19][CH2:20][C@@H:16]([O:15][CH3:14])[CH2:17]1

Participants

3

Reactant 2

HCID 51395376-Bromo-4-chloroquinolineHCID 45789898(3R)-3-methoxypyrrolidine hydrochloride

Product 1

HCID 586659576-Bromo-4-[(3R)-3-methoxytetrahydro-1H-1-pyrrolyl]quinolineYield 44.8%

Procedure

500 mg 6-bromo-4-chloroquinoline and 300 mg (3R)-3-methoxy pyrrolidine monohydrochloride were reacted by the same method as in Production Example 82, to give 284 mg of the title compound as a yellow oil.

Sources & evidence

ORD record
ord-44a5b37683ee46fc947e367ce6e12229
Source dataset
uspto-grants-2006_07
Patent number
US07074801B1

Reaction notes

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