HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Bromo-4-chloroquinoline → 6-Bromo-4-[(3R)-3-methoxytetrahydro-1H-1-pyrrolyl]quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Bromo-4-chloroquinoline | HCID 5139537 | — |
| Reactant | (3R)-3-methoxypyrrolidine hydrochloride | HCID 45789898 | — |
| Product | 6-Bromo-4-[(3R)-3-methoxytetrahydro-1H-1-pyrrolyl]quinoline | HCID 58665957 | 44.8% |
Reaction Steps
500 mg 6-bromo-4-chloroquinoline and 300 mg (3R)-3-methoxy pyrrolidine monohydrochloride were reacted by the same method as in Production Example 82, to give 284 mg of the title compound as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07074801B1 |
| Source dataset | uspto-grants-2006_07 |
| ORD ID | ord-44a5b37683ee46fc947e367ce6e12229 |
| Source note | uspto-grants-2006_07 |