6-Bromo-4-chloroquinoline → 6-Bromo-4-[4-(2-pyridyloxy)piperidino]quinoline

HRID 1792440Notes

Reaction equation

HRID 1792440 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[C:5]2Cl.Cl.Cl.[NH:15]1[CH2:20][CH2:19][CH:18]([O:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=2)[CH2:17][CH2:16]1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[C:5]2[N:15]1[CH2:20][CH2:19][CH:18]([O:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=2)[CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 51395376-Bromo-4-chloroquinolineHCID 146741542-(Piperidin-4-yloxy)pyridine dihydrochloride

Product 1

HCID 220320696-Bromo-4-[4-(2-pyridyloxy)piperidino]quinolineYield 79.4%

Procedure

500 mg 6-bromo-4-chloroquinoline and 540 mg 2-(4-piperidyloxy) pyridine dihydrochloride were reacted by the same method as in Production Example 82, to give 629 mg of the title compound as an orange oil.

Sources & evidence

ORD record
ord-2b980d3bc2484497869d7efaf50a8779
Source dataset
uspto-grants-2006_07
Patent number
US07074801B1

Reaction notes

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