Cesium carbonate → HCID 22031101, compound

HRID 1792451Notes

Reaction equation

HRID 1792451 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[C:4]([F:11])[CH:3]=1.[Br-].[CH2:13]1[CH2:17][CH2:16][CH2:15][CH2:14]1.C(=O)([O-])[O-].[Cs+].[Cs+]>C(#N)C.C(OCC)(=O)C>[CH:13]1([O:1][C:2]2[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[C:4]([F:11])[CH:3]=2)[CH2:17][CH2:16][CH2:15][CH2:14]1

Participants

6

Reactant 3

HCID 10796Cesium carbonateHCID 27249122'-Fluoro-4'-hydroxyacetophenoneHCID 22031976HCID 22031976, compound2×

Product 1

HCID 22031101HCID 22031101, compound

Reagents, catalysts & solvents 2

HCID 6342AcetonitrileSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
70 °C

Procedure

A suspension of 2.5 g 4′-hydroxy-2′-fluoroacetophenone, 2.0 mL cyclopentane bromide and 7.9 g cesium carbonate in acetonitrile (35 mL) was heated for 1 hour under reflux and then heated at 70° C. for 15 hours. Further, 1.0 mL cyclopentane bromide was added thereto, and the mixture was heated for 3 hours under reflux. The reaction mixture was diluted with ethyl acetate, washed with water and brine and dried over anhydrous sodium sulfate, and the solvent was removed, whereby 3.65 g of the title compound in a crude state (yellow oil) was obtained.

Workup

  1. temperaturewas heated for 1 hour
  2. temperatureunder reflux
  3. temperaturethe mixture was heated for 3 hours
  4. temperatureunder reflux
  5. washwashed with water and brine
  6. dry with materialdried over anhydrous sodium sulfate
  7. customthe solvent was removed

Sources & evidence

ORD record
ord-2159859012fe4ea19678cdf3cfd8ed9c
Source dataset
uspto-grants-2006_07
Patent number
US07074801B1

Reaction notes

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