N-Iodosuccinimide → HCID 22031205, compound

HRID 1792470Notes

Reaction equation

HRID 1792470 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[S:6][CH2:7][CH2:8][CH2:9][C:10]#[N:11].[I:12]N1C(=O)CCC1=O>CN(C)C=O>[I:12][C:5]1[S:1][C:2]([S:6][CH2:7][CH2:8][CH2:9][C:10]#[N:11])=[CH:3][CH:4]=1

Participants

4

Reactant 2

HCID 120273N-IodosuccinimideHCID 22030969HCID 22030969, compound

Product 1

HCID 22031205HCID 22031205, compoundYield 95.9%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2.3 g of thiophen-2-thiol, 3.0 g of 4-bromobutyronitrile and 5.5 g of potassium carbonate were stirred in N,N-dimethylformamide at room temperature to give 3.4 g of 4-(2-thienylsulfanyl)butane nitrile. 3.4 g of 4-(2-thienylsulfanyl)butane nitrile was reacted with 5.4 g of N-iodosuccinimide in N,N-dimethylformamide, whereby 5.5 g of the title compound was obtained as a pale yellow oil.

Sources & evidence

ORD record
ord-65f4b916b44c4c289686bb041aa72e0e
Source dataset
uspto-grants-2006_07
Patent number
US07074801B1

Reaction notes

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