Trifluoroacetic acid → HCID 22032162, compound

HRID 1792488Notes

Reaction equation

HRID 1792488 reaction equation
FC(F)(F)C(O)=O.[C:8]([C:10]1[CH:11]=[C:12]([N:17]2[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]2)[CH:13]=[CH:14][C:15]=1[F:16])#[N:9].O.N>>[F:16][C:15]1[CH:14]=[CH:13][C:12]([N:17]2[CH2:18][CH2:19][NH:20][CH2:21][CH2:22]2)=[CH:11][C:10]=1[C:8]#[N:9]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12896473Azane;hydrateHCID 22032003HCID 22032003, compound

Product 1

HCID 22032162HCID 22032162, compoundYield 101.2%

Procedure

Trifluoroacetic acid was added to 500 mg of t-butyl 4-(3-cyano-4-fluorophenyl)-1-piperazinecarboxylate (compound in Production Example 354) and stirred at room temperature for several hours. After the reaction solution was cooled on ice, ammonia water was added thereto and stirred, the aqueous layer was extracted with dichloromethane, and all the organic layer was combined, dried and concentrated to give 340 mg of the title compound.

Workup

  1. additionwas added
  2. stirringstirred
  3. extractionthe aqueous layer was extracted with dichloromethane
  4. customdried
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-f14653ef79f24d6b9ac4bda8f513752b
Source dataset
uspto-grants-2006_07
Patent number
US07074801B1

Reaction notes

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