反应详情

温度

60 °C

14.4 mL chlorosulfonic acid and 14.42 mL thionyl chloride were added to 7.78 g of 6-bromo-4-(2-thienyl)quinazoline (compound in Production Example 96) under ice-cooling in a stream of nitrogen, and the mixture was heated at 60° C. for 16 hours, then poured into iced water, neutralized by adding a sodium bicarbonate solution and extracted with dichloromethane. The organic layer was dried over anhydrous sodium sulfate. The residue was recrystallized from ether/hexane, to give 2.47 g of the title compound (pale skin-colored crystals).

1. temperaturecooling in a stream of nitrogen
2. extractionextracted with dichloromethane
3. dry with materialThe organic layer was dried over anhydrous sodium sulfate
4. customThe residue was recrystallized from ether/hexane