Water → HCID 22031755, compound

HRID 1792493Notes

Reaction equation

HRID 1792493 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][N:6]=[C:5]2[C:12]1[S:13][C:14]([CH:17](OCC)[O:18]CC)=[CH:15][CH:16]=1.FC(F)(F)C(O)=O.O>ClCCl>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][N:6]=[C:5]2[C:12]1[S:13][C:14]([CH:17]=[O:18])=[CH:15][CH:16]=1

Participants

5

Reactant 3

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 22032410HCID 22032410, compound

Product 1

HCID 22031755HCID 22031755, compoundYield 98.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2.6 g of 6-bromo-4-(5-diethoxymethylthiophen-2-yl)quinazoline (compound in Production Example 380) was dissolved in 10 mL dichloromethane, then 5 mL trifluoroacetic acid was added thereto, and the mixture was stirred at room temperature for 3 hours, neutralized by adding water and a sodium bicarbonate solution, and extracted with dichloromethane. The organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated, whereby 2.07 g of the title compound was obtained as pale yellow crystals.

Workup

  1. extractiona sodium bicarbonate solution, and extracted with dichloromethane
  2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  3. customthe solvent was evaporated

Sources & evidence

ORD record
ord-6519ac15518343e7928c1bc845e13259
Source dataset
uspto-grants-2006_07
Patent number
US07074801B1

Reaction notes

Loading…