Hydrochloric Acid → HCID 178505587, compound

HRID 1792546Notes

Reaction equation

HRID 1792546 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:13]3[CH:14]=[C:15]4[C:20](=[CH:21][CH:22]=3)[N:19]=[CH:18][CH:17]=[C:16]4[C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=3)=[CH:11][N:10](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[N:9]=2)=[CH:4][CH:3]=1.Cl>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:13]3[CH:14]=[C:15]4[C:20](=[CH:21][CH:22]=3)[N:19]=[CH:18][CH:17]=[C:16]4[C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=3)=[CH:11][NH:10][N:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 220319916-[3-(4-fluorophenyl)-1-trityl-1H-4-pyrazolyl]-4-(2-pyridyl)quinoline

Product 1

HCID 178505587HCID 178505587, compoundYield 52.7%

Procedure

63 mg 6-[3-(4-fluorophenyl)-1-trityl-1H-4-pyrazolyl]-4-(2-pyridyl)quinoline obtained in Example 159 and 0.82 mL of 5 N hydrochloric acid were reacted in the same manner as in Example 162, to give 20 mg of the title compound as a colorless amorphous.

Sources & evidence

ORD record
ord-3181d23a9dd14fb98bb8fba7495710e3
Source dataset
uspto-grants-2006_07
Patent number
US07074801B1

Reaction notes

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