Trifluoroacetic acid → HCID 178504676, compound

HRID 1792547Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:13]3[CH:14]=[C:15]4[C:20](=[CH:21][CH:22]=3)[N:19]=[CH:18][CH:17]=[C:16]4[C:23]3[S:24][C:25]([S:28]([CH3:31])(=[O:30])=[O:29])=[CH:26][CH:27]=3)=[CH:11][N:10](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[N:9]=2)=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:13]3[CH:14]=[C:15]4[C:20](=[CH:21][CH:22]=3)[N:19]=[CH:18][CH:17]=[C:16]4[C:23]3[S:24][C:25]([S:28]([CH3:31])(=[O:30])=[O:29])=[CH:26][CH:27]=3)=[CH:11][NH:10][N:9]=2)=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 22031711HCID 22031711, compound

Product 1

HCID 178504676HCID 178504676, compoundYield 55.2%

Procedure

39 mg 6-[3-(4-fluorophenyl)-1-trityl-1H-4-pyrazolyl]-4-(5-methylsulfonyl 2-thienyl)quinoline obtained in Example 167 and 0.5 mL trifluoroacetic acid were reacted in the same manner as in Example 165, to give 14 mg of the title compound as pale yellow crystals.

Sources & evidence

ORD record: ord-95ef89c048094408b4b9ce7fb4060e93
Source dataset: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07074801B1

Reaction notes

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