N,N-Dimethylethylenediamine → HCID 22031669, compound

HRID 1792555Notes

Reaction equation

HRID 1792555 reaction equation
[N:1]1([C:6]([N:8]2[CH2:13][CH2:12][N:11]([C:14]3[C:23]4[C:18](=[CH:19][CH:20]=[C:21]([C:24]5[C:25]([CH3:48])=[N:26][N:27]([C:29]([C:42]6[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=6)([C:36]6[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=6)[C:30]6[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=6)[CH:28]=5)[CH:22]=4)[N:17]=[CH:16][CH:15]=3)[CH2:10][CH2:9]2)=[O:7])[CH:5]=[CH:4][N:3]=[CH:2]1.[CH3:49]N(C)CCN>>[CH3:2][N:3]([CH3:49])[CH2:4][CH2:5][NH:1][C:6]([N:8]1[CH2:9][CH2:10][N:11]([C:14]2[C:23]3[C:18](=[CH:19][CH:20]=[C:21]([C:24]4[C:25]([CH3:48])=[N:26][N:27]([C:29]([C:36]5[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=5)([C:42]5[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=5)[C:30]5[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=5)[CH:28]=4)[CH:22]=3)[N:17]=[CH:16][CH:15]=2)[CH2:12][CH2:13]1)=[O:7]

Participants

3

Reactant 2

HCID 66053N,N-DimethylethylenediamineHCID 23537685HCID 23537685, compound

Product 1

HCID 22031669HCID 22031669, compound

Procedure

60 mg 1H-1-imidazolyl{4-[6-(3-methyl-1-trityl-1H-pyrazolyl)-4-quinolyl]piperazin-1-yl)methanone obtained in Example 195 and 1 mL N,N-dimethylethylene diamine were reacted in the same manner as in Example 196, to give 29 mg of the title compound as a pale yellow oil.

Sources & evidence

ORD record
ord-b5fe881050714fe1ab8d15203f94e7b7
Source dataset
uspto-grants-2006_07
Patent number
US07074801B1

Reaction notes

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