Trifluoroacetic acid → HCID 178480769, compound

HRID 1792558Notes

Reaction equation

HRID 1792558 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]4[C:19]([C:42](F)(F)[F:43])=[N:20][N:21](C(C5C=CC=CC=5)(C5C=CC=CC=5)C5C=CC=CC=5)[CH:22]=4)[CH:16]=3)[N:11]=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.FC(F)(F)C(O)=O>>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]4[C:19]([CH2:42][F:43])=[N:20][NH:21][CH:22]=4)[CH:16]=3)[N:11]=[CH:10][CH:9]=2)[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22031132HCID 22031132, compound

Product 1

HCID 178480769HCID 178480769, compoundYield 52.8%

Procedure

123 mg 4-(4-methylpiperazin-1-yl)-6-(3-trifluoromethyl-1-trityl-1H-4-pyrazolyl)quinoline obtained in Example 170 and 0.7 mL trifluoroacetic acid were reacted in the same manner as in Example 165, to give 35 mg of the title compound as pale yellow crystals.

Sources & evidence

ORD record
ord-3c7208a5cea642e29aa21bdb58cb18d5
Source dataset
uspto-grants-2006_07
Patent number
US07074801B1

Reaction notes

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