Trifluoroacetic acid → HCID 178506297, compound

HRID 1792561Notes

Reaction equation

HRID 1792561 reaction equation
[F:1][C:2]([F:44])([F:43])[C:3]1[C:7]([C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[N:14]=[CH:13][CH:12]=[C:11]3[N:18]2[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)=[CH:6][N:5](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[N:4]=1.FC(F)(F)C(O)=O>>[F:44][C:2]([F:1])([F:43])[C:3]1[C:7]([C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[N:14]=[CH:13][CH:12]=[C:11]3[N:18]2[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)=[CH:6][NH:5][N:4]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22032098HCID 22032098, compound

Product 1

HCID 178506297HCID 178506297, compoundYield 79.2%

Procedure

122 mg 4-[6-(3-trifluoromethyl-1-trityl-1H-4-pyrazolyl)-4-quinolyl]morpholine obtained in Example 174 and 1.5 mL trifluoroacetic acid were reacted in the same manner as in Example 165, to give 57 mg of the title compound as pale yellow crystals.

Sources & evidence

ORD record
ord-b5e3293d59c64c3fac06886202154089
Source dataset
uspto-grants-2006_07
Patent number
US07074801B1

Reaction notes

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