Hydrochloric Acid → HCID 22032077, compound

HRID 1792562Notes

Reaction equation

HRID 1792562 reaction equation
[F:1][C:2]([F:50])([F:49])[C:3]1[CH:4]=[C:5]([N:9]2[CH2:14][CH2:13][N:12]([C:15]3[C:24]4[C:19](=[CH:20][CH:21]=[C:22]([C:25]5[CH:26]=[N:27][N:28](C(C6C=CC=CC=6)(C6C=CC=CC=6)C6C=CC=CC=6)[CH:29]=5)[CH:23]=4)[N:18]=[CH:17][CH:16]=3)[CH2:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1.[ClH:51]>>[ClH:51].[ClH:51].[NH:27]1[CH:26]=[C:25]([C:22]2[CH:23]=[C:24]3[C:19](=[CH:20][CH:21]=2)[N:18]=[CH:17][CH:16]=[C:15]3[N:12]2[CH2:11][CH2:10][N:9]([C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:50])[F:49])[CH:4]=3)[CH2:14][CH2:13]2)[CH:29]=[N:28]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 22032021HCID 22032021, compound

Product 1

HCID 22032077HCID 22032077, compound

Procedure

104 mg 4-[4-(3-trifluoromethylphenyl)piperazin-1-yl]-6-(1-trityl-1H-4-pyrazolyl) quinoline obtained in Example 175 and 1.2 mL of 5 N hydrochloric acid were reacted in the same manner as in Example 163, to give 74 mg of the title compound as yellowish orange crystals.

Sources & evidence

ORD record
ord-69fe0d25ba7b4eaf8d68e3a44e389760
Source dataset
uspto-grants-2006_07
Patent number
US07074801B1

Reaction notes

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