Hydrochloric Acid → HCID 178434500, compound

HRID 1792563Notes

Reaction equation

[CH3:1][C:2]1[C:6]([C:7]2[CH:8]=[C:9]3[C:14](=[CH:15][CH:16]=2)[N:13]=[CH:12][CH:11]=[C:10]3[N:17]2[CH2:22][CH2:21][N:20]([C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:32])([F:31])[F:30])[CH:24]=3)[CH2:19][CH2:18]2)=[CH:5][N:4](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[N:3]=1.[ClH:52]>>[ClH:52].[ClH:52].[CH3:1][C:2]1[C:6]([C:7]2[CH:8]=[C:9]3[C:14](=[CH:15][CH:16]=2)[N:13]=[CH:12][CH:11]=[C:10]3[N:17]2[CH2:18][CH2:19][N:20]([C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:32])([F:30])[F:31])[CH:24]=3)[CH2:21][CH2:22]2)=[CH:5][NH:4][N:3]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 22031230HCID 22031230, compound

Product 1

HCID 178434500HCID 178434500, compound

Procedure

115 mg 6-(3-methyl-1-trityl-1H-4-pyrazolyl)-4-[4-(3-trifluoromethylphenyl)piperazin-1-yl]quinoline obtained in Example 176 and 1.3 mL of 5 N hydrochloric acid were reacted in the same manner as in Example 163, to give 68 mg of the title compound as yellowish orange crystals.

Sources & evidence

ORD record: ord-a77d00bc0b204e07806b806be3665099
Source dataset: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07074801B1

Reaction notes

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