Hydrochloric Acid → HCID 178490803, compound

HRID 1792564Notes

Reaction equation

[CH3:1][O:2][C:3]1[N:8]=[C:7]([N:9]2[CH2:14][CH2:13][N:12]([C:15]3[C:24]4[C:19](=[CH:20][CH:21]=[C:22]([C:25]5[C:26]([CH3:49])=[N:27][N:28](C(C6C=CC=CC=6)(C6C=CC=CC=6)C6C=CC=CC=6)[CH:29]=5)[CH:23]=4)[N:18]=[CH:17][CH:16]=3)[CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=1.[ClH:50]>>[ClH:50].[ClH:50].[ClH:50].[CH3:1][O:2][C:3]1[N:8]=[C:7]([N:9]2[CH2:10][CH2:11][N:12]([C:15]3[C:24]4[C:19](=[CH:20][CH:21]=[C:22]([C:25]5[C:26]([CH3:49])=[N:27][NH:28][CH:29]=5)[CH:23]=4)[N:18]=[CH:17][CH:16]=3)[CH2:13][CH2:14]2)[CH:6]=[CH:5][CH:4]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 22031733HCID 22031733, compound

Product 1

HCID 178490803HCID 178490803, compound

Procedure

120 mg 4-[4-(6-methoxy-2-pyridyl)piperazin-1-yl]-6-(3-methyl-1-trityl-1H-4-pyrazolyl)quinoline obtained in Example 178 and 1.4 mL of 5 N— hydrochloric acid were reacted in the same manner as in Example 163, to give 87 mg of the title compound as pale yellow crystals.

Sources & evidence

ORD record: ord-0c3b30bb85944f5b82385e78c33a431a
Source dataset: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07074801B1

Reaction notes

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