Hydrochloric Acid → HCID 178434504, compound

HRID 1792565Notes

Reaction equation

HRID 1792565 reaction equation
[CH3:1][C:2]1[C:6]([C:7]2[CH:8]=[C:9]3[C:14](=[CH:15][CH:16]=2)[N:13]=[CH:12][CH:11]=[C:10]3[N:17]2[CH2:22][CH2:21][N:20]([C:23]([NH2:25])=[O:24])[CH2:19][CH2:18]2)=[CH:5][N:4](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[N:3]=1.Cl>>[CH3:1][C:2]1[C:6]([C:7]2[CH:8]=[C:9]3[C:14](=[CH:15][CH:16]=2)[N:13]=[CH:12][CH:11]=[C:10]3[N:17]2[CH2:22][CH2:21][N:20]([C:23]([NH2:25])=[O:24])[CH2:19][CH2:18]2)=[CH:5][NH:4][N:3]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 22031903HCID 22031903, compound

Product 1

HCID 178434504HCID 178434504, compoundYield 42.1%

Procedure

94 mg 4-[6-(3-methyl-1-trityl-1H-4-pyrazolyl)-4-quinolyl]-1-piperazine carboxamide obtained in Example 179 and 1.3 mL of 5 N hydrochloric acid were reacted in the same manner as in Example 162, to give 23 mg of the title compound as a pale yellow solid.

Sources & evidence

ORD record
ord-e54decf0ba884e2fac60d8d3fd7aa45c
Source dataset
uspto-grants-2006_07
Patent number
US07074801B1

Reaction notes

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