Hydrochloric Acid → HCID 178465279, compound

HRID 1792566Notes

Reaction equation

[CH2:1]([NH:3][C:4]([N:6]1[CH2:11][CH2:10][N:9]([C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[C:19]([C:22]4[C:23]([CH3:46])=[N:24][N:25](C(C5C=CC=CC=5)(C5C=CC=CC=5)C5C=CC=CC=5)[CH:26]=4)[CH:20]=3)[N:15]=[CH:14][CH:13]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2].[ClH:47]>>[ClH:47].[ClH:47].[CH2:1]([NH:3][C:4]([N:6]1[CH2:7][CH2:8][N:9]([C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[C:19]([C:22]4[C:23]([CH3:46])=[N:24][NH:25][CH:26]=4)[CH:20]=3)[N:15]=[CH:14][CH:13]=2)[CH2:10][CH2:11]1)=[O:5])[CH3:2]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 23537781HCID 23537781, compound

Product 1

HCID 178465279HCID 178465279, compound

Procedure

118 mg N-ethyl-4-[6-(3-methyl-1-trityl-1H-pyrazolyl)-4-quinolyl]-1-piperazine carboxamide obtained in Example 180 and 1.5 mL of 5 N hydrochloric acid were reacted in the same manner as in Example 163, to give 72 mg of the title compound as a pale yellow solid.

Sources & evidence

ORD record: ord-db04afed677749f3810ef391a58a6385
Source dataset: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07074801B1

Reaction notes

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