Trifluoroacetic acid → HCID 178434508, compound

HRID 1792568Notes

Reaction equation

[CH3:1][N:2]([CH3:46])[C:3]([N:5]1[CH2:10][CH2:9][N:8]([C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([C:21]4[C:22]([CH3:45])=[N:23][N:24](C(C5C=CC=CC=5)(C5C=CC=CC=5)C5C=CC=CC=5)[CH:25]=4)[CH:19]=3)[N:14]=[CH:13][CH:12]=2)[CH2:7][CH2:6]1)=[O:4].FC(F)(F)C(O)=O>>[CH3:1][N:2]([CH3:46])[C:3]([N:5]1[CH2:6][CH2:7][N:8]([C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([C:21]4[C:22]([CH3:45])=[N:23][NH:24][CH:25]=4)[CH:19]=3)[N:14]=[CH:13][CH:12]=2)[CH2:9][CH2:10]1)=[O:4]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 23537795HCID 23537795, compound

Product 1

HCID 178434508HCID 178434508, compoundYield 70.1%

Procedure

38 mg N,N-dimethyl 4-[6-(3-methyl-1-trityl-1H-pyrazolyl)-4-quinolyl]-1-piperazine carboxamide obtained in Example 182 and 0.2 mL trifluoroacetic acid were reacted in the same manner as in Example 165, to give 16 mg of the title compound as pale yellow crystals.

Sources & evidence

ORD record: ord-5f2bbce63b7b434e86998dcb5ac0ff9f
Source dataset: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07074801B1

Reaction notes

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