Trifluoroacetic acid → HCID 178434502, compound

HRID 1792572Notes

Reaction equation

[CH3:1][C:2]1[C:6]([C:7]2[CH:8]=[C:9]3[C:14](=[CH:15][CH:16]=2)[N:13]=[CH:12][CH:11]=[C:10]3[N:17]2[CH2:22][CH2:21][N:20]([CH2:23][C:24]([NH2:26])=[O:25])[CH2:19][CH2:18]2)=[CH:5][N:4](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[N:3]=1.FC(F)(F)C(O)=O>>[CH3:1][C:2]1[C:6]([C:7]2[CH:8]=[C:9]3[C:14](=[CH:15][CH:16]=2)[N:13]=[CH:12][CH:11]=[C:10]3[N:17]2[CH2:22][CH2:21][N:20]([CH2:23][C:24]([NH2:26])=[O:25])[CH2:19][CH2:18]2)=[CH:5][NH:4][N:3]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 22031098HCID 22031098, compound

Product 1

HCID 178434502HCID 178434502, compoundYield 34.7%

Procedure

39 mg 2-{4-[6-(3-methyl-1-trityl-1H-4-pyrazolyl)-4-quinolyl]piperazin-1-yl}acetamide obtained in Example 190 and 1 mL trifluoroacetic acid were reacted in the same manner as in Example 165, to give 8 mg of the title compound as a pale yellow solid.

Sources & evidence

ORD record: ord-eb96437062ab4d75bb126321ca9d71d6
Source dataset: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07074801B1

Reaction notes

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