Trifluoroacetic acid → HCID 178434503, compound

HRID 1792573Notes

Reaction equation

[CH3:1][N:2]([CH3:47])[C:3](=[O:46])[CH2:4][N:5]1[CH2:10][CH2:9][N:8]([C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([C:21]4[C:22]([CH3:45])=[N:23][N:24](C(C5C=CC=CC=5)(C5C=CC=CC=5)C5C=CC=CC=5)[CH:25]=4)[CH:19]=3)[N:14]=[CH:13][CH:12]=2)[CH2:7][CH2:6]1.FC(F)(F)C(O)=O>>[CH3:47][N:2]([CH3:1])[C:3](=[O:46])[CH2:4][N:5]1[CH2:10][CH2:9][N:8]([C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([C:21]4[C:22]([CH3:45])=[N:23][NH:24][CH:25]=4)[CH:19]=3)[N:14]=[CH:13][CH:12]=2)[CH2:7][CH2:6]1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 22031443HCID 22031443, compound

Product 1

HCID 178434503HCID 178434503, compoundYield 16%

Procedure

82 mg N,N-dimethyl-2-{4-[6-(3-methyl-1-trityl-1H-4-pyrazolyl)-4-quinolyl]piperazin-1-yl}acetamide obtained in Example 191 and 1 mL trifluoroacetic acid were reacted in the same manner as in Example 165, to give 8 mg of the title compound as pale yellow crystals.

Sources & evidence

ORD record: ord-a10340c9c9cf4b83b77c8347d8763718
Source dataset: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07074801B1

Reaction notes

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