Trifluoroacetic acid → HCID 178521672, compound

HRID 1792574Notes

Reaction equation

[O:1]1[CH2:6][CH2:5][N:4]([C:7]([N:9]2[CH2:14][CH2:13][N:12]([C:15]3[C:24]4[C:19](=[CH:20][CH:21]=[C:22]([C:25]5[C:26]([C:49]([F:52])([F:51])[F:50])=[N:27][N:28](C(C6C=CC=CC=6)(C6C=CC=CC=6)C6C=CC=CC=6)[CH:29]=5)[CH:23]=4)[N:18]=[CH:17][CH:16]=3)[CH2:11][CH2:10]2)=[O:8])[CH2:3][CH2:2]1.FC(F)(F)C(O)=O>>[O:1]1[CH2:6][CH2:5][N:4]([C:7]([N:9]2[CH2:14][CH2:13][N:12]([C:15]3[C:24]4[C:19](=[CH:20][CH:21]=[C:22]([C:25]5[C:26]([C:49]([F:52])([F:50])[F:51])=[N:27][NH:28][CH:29]=5)[CH:23]=4)[N:18]=[CH:17][CH:16]=3)[CH2:11][CH2:10]2)=[O:8])[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 23537689HCID 23537689, compound

Product 1

HCID 178521672HCID 178521672, compoundYield 81.9%

Procedure

123 mg morpholino{4-[6-(3-trifluoromethyl-1-trityl-1H-pyrazolyl)-4-quinolyl]piperazin-1-yl}methanone obtained in Example 193 and 1.5 mL trifluoroacetic acid were reacted in the same manner as in Example 165, to give 66 mg of the title compound as a pale yellow amorphous.

Sources & evidence

ORD record: ord-3fe30596bbcc4fbfb0b9dde94216350a
Source dataset: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07074801B1

Reaction notes

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