Hydrochloric Acid → HCID 178434506, compound

HRID 1792575Notes

Reaction equation

[CH3:1][C:2]1[C:6]([C:7]2[CH:8]=[C:9]3[C:14](=[CH:15][CH:16]=2)[N:13]=[CH:12][CH:11]=[C:10]3[N:17]2[CH2:22][CH2:21][N:20]([C:23]([N:25]3[CH2:30][CH2:29][O:28][CH2:27][CH2:26]3)=[O:24])[CH2:19][CH2:18]2)=[CH:5][N:4](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[N:3]=1.[ClH:50]>>[ClH:50].[CH3:1][C:2]1[C:6]([C:7]2[CH:8]=[C:9]3[C:14](=[CH:15][CH:16]=2)[N:13]=[CH:12][CH:11]=[C:10]3[N:17]2[CH2:18][CH2:19][N:20]([C:23]([N:25]3[CH2:30][CH2:29][O:28][CH2:27][CH2:26]3)=[O:24])[CH2:21][CH2:22]2)=[CH:5][NH:4][N:3]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 22032159HCID 22032159, compound

Product 1

HCID 178434506HCID 178434506, compound

Procedure

90 mg 4-[6-(3-methyl-1-trityl-1H-4-pyrazolyl)-4-quinolyl]piperazin-1-yl-(morpholino)methanone obtained in Example 196 and 1 mL of 5 N hydrochloric acid were reacted in the same manner as in Example 163, to give 36 mg of the title compound as a yellow solid.

Sources & evidence

ORD record: ord-adf4bd1ca14c45bcb01b1ed112ba5ae0
Source dataset: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07074801B1

Reaction notes

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