Hydrochloric Acid → HCID 178434510, compound

HRID 1792576Notes

Reaction equation

[CH3:1][N:2]([CH3:49])[CH2:3][CH2:4][NH:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:23]3[C:18](=[CH:19][CH:20]=[C:21]([C:24]4[C:25]([CH3:48])=[N:26][N:27](C(C5C=CC=CC=5)(C5C=CC=CC=5)C5C=CC=CC=5)[CH:28]=4)[CH:22]=3)[N:17]=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=[O:7].Cl>>[CH3:1][N:2]([CH3:49])[CH2:3][CH2:4][NH:5][C:6]([N:8]1[CH2:9][CH2:10][N:11]([C:14]2[C:23]3[C:18](=[CH:19][CH:20]=[C:21]([C:24]4[C:25]([CH3:48])=[N:26][NH:27][CH:28]=4)[CH:22]=3)[N:17]=[CH:16][CH:15]=2)[CH2:12][CH2:13]1)=[O:7]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 22031669HCID 22031669, compound

Product 1

HCID 178434510HCID 178434510, compoundYield 9.4%

Procedure

27 mg N-[2-(dimethylamino)ethyl]-4-[6-(3-methyl-1-trityl-1H-4-pyrazolyl)-4-quinolyl]-1-piperazine carboxamide obtained in Example 197 and 0.32 mL of 5 N hydrochloric acid were reacted in the same manner as in Example 162, to give 1.6 mg of the title compound as a pale yellow solid.

Sources & evidence

ORD record: ord-e0b88ebbfed6437a920d36f3366795aa
Source dataset: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07074801B1

Reaction notes

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