Hydrochloric Acid → HCID 178434509, compound

HRID 1792577Notes

Reaction equation

[CH3:1][N:2]([CH3:50])[CH2:3][CH2:4][N:5]([CH3:49])[C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:23]3[C:18](=[CH:19][CH:20]=[C:21]([C:24]4[C:25]([CH3:48])=[N:26][N:27](C(C5C=CC=CC=5)(C5C=CC=CC=5)C5C=CC=CC=5)[CH:28]=4)[CH:22]=3)[N:17]=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=[O:7].[ClH:51]>>[ClH:51].[ClH:51].[CH3:1][N:2]([CH3:50])[CH2:3][CH2:4][N:5]([CH3:49])[C:6]([N:8]1[CH2:9][CH2:10][N:11]([C:14]2[C:23]3[C:18](=[CH:19][CH:20]=[C:21]([C:24]4[C:25]([CH3:48])=[N:26][NH:27][CH:28]=4)[CH:22]=3)[N:17]=[CH:16][CH:15]=2)[CH2:12][CH2:13]1)=[O:7]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 22031780HCID 22031780, compound

Product 1

HCID 178434509HCID 178434509, compound

Procedure

67 mg N-[2-(dimethylamino)ethyl]-N-methyl-4-[6-(3-methyl-1-trityl-1H-4-pyrazolyl)-4-quinolyl]-1-piperazine carboxamide obtained in Example 198 and 0.72 mL of 5 N hydrochloric acid were reacted in the same manner as in Example 163, to give 37 mg of the title compound as pale yellow crystals.

Sources & evidence

ORD record: ord-9164d306f0164298ac7f831a50b2bef4
Source dataset: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07074801B1

Reaction notes

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