Hydrochloric Acid → HCID 22031092, compound

HRID 1792615Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:4][C:3]=1[N:12]1[CH2:17][CH2:16][N:15]([C:18]2[C:27]3[C:22](=[CH:23][CH:24]=[C:25]([C:28]4[CH:29]=[N:30][N:31](C(C5C=CC=CC=5)(C5C=CC=CC=5)C5C=CC=CC=5)[CH:32]=4)[CH:26]=3)[N:21]=[CH:20][N:19]=2)[CH2:14][CH2:13]1.[ClH:52]>>[ClH:52].[ClH:52].[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:4][C:3]=1[N:12]1[CH2:13][CH2:14][N:15]([C:18]2[C:27]3[C:22](=[CH:23][CH:24]=[C:25]([C:28]4[CH:32]=[N:31][NH:30][CH:29]=4)[CH:26]=3)[N:21]=[CH:20][N:19]=2)[CH2:16][CH2:17]1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 23537442HCID 23537442, compound

Product 1

HCID 22031092HCID 22031092, compound

Procedure

211 mg 4-[4-(2-fluoro-5-methylsulfonylphenyl)piperazin-1-yl]-6-(1-trityl-1H-4-pyrazolyl) quinazoline obtained in Example 730 was subjected to deprotection of the trityl group and converted into the corresponding hydrochloride by the same method as in Example 163, to give 108 mg of the title compound as pale yellow crystals.

Sources & evidence

ORD record: ord-8c88d7a76a9f499da572a99c1cb3a47f
Source dataset: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07074801B1

Reaction notes

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