Hydrochloric Acid → HCID 22032383, compound

HRID 1792616Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([N:12]2[CH2:17][CH2:16][N:15]([C:18]3[C:27]4[C:22](=[CH:23][CH:24]=[C:25]([C:28]5[CH:29]=[N:30][N:31](C(C6C=CC=CC=6)(C6C=CC=CC=6)C6C=CC=CC=6)[CH:32]=5)[CH:26]=4)[N:21]=[CH:20][N:19]=3)[CH2:14][CH2:13]2)[CH:5]=[C:6]([S:8]([CH3:11])(=[O:10])=[O:9])[CH:7]=1.[ClH:52]>>[ClH:52].[ClH:52].[F:1][C:2]1[CH:3]=[C:4]([N:12]2[CH2:17][CH2:16][N:15]([C:18]3[C:27]4[C:22](=[CH:23][CH:24]=[C:25]([C:28]5[CH:32]=[N:31][NH:30][CH:29]=5)[CH:26]=4)[N:21]=[CH:20][N:19]=3)[CH2:14][CH2:13]2)[CH:5]=[C:6]([S:8]([CH3:11])(=[O:10])=[O:9])[CH:7]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 22032482HCID 22032482, compound

Product 1

HCID 22032383HCID 22032383, compound

Procedure

130 mg 4-[4-(3-fluoro-5-methylsulfonylphenyl)piperazin-1-yl]-6-(1-trityl-1H-4-pyrazolyl)quinazoline obtained in Example 731 was subjected to deprotection of the trityl group and converted into the corresponding hydrochloride by the same method as in Example 163, to give 62 mg of the title compound as pale yellow crystals. 1H-NMR data are those of the salt in a free form.

Sources & evidence

ORD record: ord-356fc77c65014b1e9dead48542a6fbda
Source dataset: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07074801B1

Reaction notes

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