Hydrochloric Acid → HCID 23540227, compound

HRID 1792780Notes

Reaction equation

HRID 1792780 reaction equation
Cl.[NH2:2][C@@H:3]([C:7]([N:9]1[CH2:14][CH2:13][N:12]([CH:15]2[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]2)[CH2:11][CH2:10]1)=[O:8])[C@@H:4]([CH3:6])[OH:5].[Cl:22][C:23]1[CH:24]=[C:25]2[C:29](=[CH:30][CH:31]=1)[NH:28][C:27]([C:32](O)=[O:33])=[CH:26]2.Cl>>[ClH:22].[Cl:22][C:23]1[CH:24]=[C:25]2[C:29](=[CH:30][CH:31]=1)[NH:28][C:27]([C:32]([NH:2][C@@H:3]([C:7]([N:9]1[CH2:14][CH2:13][N:12]([CH:15]3[CH2:16][CH2:17][N:18]([CH3:21])[CH2:19][CH2:20]3)[CH2:11][CH2:10]1)=[O:8])[C@@H:4]([CH3:6])[OH:5])=[O:33])=[CH:26]2

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 826935-Chloro-1H-indole-2-carboxylic acidHCID 23540199HCID 23540199, compound

Product 1

HCID 23540227HCID 23540227, compound

Procedure

Prepared from 1-(D-allo-threoninyl)-4-(1-methylpiperidin-4-yl)piperazine hydrochloride and 5-chloroindole-2-carboxylic acid using methods substantially equivalent to General Coupling Method 1. The HCl salt is prepared following Salt Formation Method 1. The final crude product is treated with aqueous 0.2 N HCl and purified via prep-HPLC (80:20 to 40:60 0.01% HCl in water:acetonitrile).

Workup

  1. custompurified via prep-HPLC (80:20 to 40:60 0.01% HCl in water:acetonitrile)

Sources & evidence

ORD record
ord-7b3ab442c5d74a1997cdacd358df9401
Source dataset
uspto-grants-2006_07
Patent number
US07078415B2

Reaction notes

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