反应详情

温度

100 °C

1.73 g (12.5 mmol) of potassium carbonate are added at 20° C. under an argon atmosphere to 0.625 g (5 mmol) of 3-methoxycarbonyl-1H-pyrrole and 0.82 g (5 mmol) of 2-chloroquinoline dissolved in 10 mL of dimethyl sulphoxide. After stirring at 100° C. for 23 hours, the reaction mixture is poured into 30 mL of water and is then allowed to crystallise at 20° C. for 1 hour. After filtering off and air-drying the solid residue, 0.83 g of 3-methoxycarbonyl-1-(quinol-2-yl)-1H-pyrrole is obtained in the form of a beige-coloured solid melting at 136° C.

1. customto crystallise at 20° C. for 1 hour
2. filtrationAfter filtering off
3. customair-drying the solid residue