反应详情

温度

110 °C

1.73 g (12.5 mmol) of potassium carbonate are added to 1.036 g (5 mmol) of 3-ethoxycarbonyl-4-trifluoromethyl-1H-pyrrole and 0.82 g (5 mmol) of 4-chloroquinoline dissolved in 10 mL of dimethyl sulphoxide at a temperature in the region of 20° C. under an argon atmosphere. After stirring for 18 hours at a temperature in the region of 110° C., the reaction mixture is poured into 30 mL of water and then left to crystallize for 1 hour at 20° C. After the solid residue has been filtered off and air-dried, 1.48 g of 3-ethoxycarbonyl-4-trifluoromethyl-1-(quinolin-4-yl)-1H-pyrrole are obtained in the form of beige-colored crystals melting at 108° C. IR spectrum (KBr): 3139; 1718; 1564; 1537; 1511; 1306; 1281; 1249; 1169; 1146; 1123; 1036; 846 and 773 cm1.

1. waitleft
2. customto crystallize for 1 hour at 20° C
3. filtrationAfter the solid residue has been filtered off
4. customair-dried