Hydrochloric Acid → HCID 22024599, compound

HRID 1793103Notes

Reaction equation

HRID 1793103 reaction equation
[OH-].[Na+].[CH3:3][C:4]1[CH:9]=[C:8]([CH3:10])[CH:7]=[CH:6][C:5]=1[C:11]1[C:12]2[N:13]([C:17]([C:22]([O:24]C)=[O:23])=[C:18]([CH2:20][CH3:21])[N:19]=2)[N:14]=[CH:15][CH:16]=1.Cl>C(O)C>[CH3:3][C:4]1[CH:9]=[C:8]([CH3:10])[CH:7]=[CH:6][C:5]=1[C:11]1[C:12]2[N:13]([C:17]([C:22]([OH:24])=[O:23])=[C:18]([CH2:20][CH3:21])[N:19]=2)[N:14]=[CH:15][CH:16]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22024701HCID 22024701, compound

Product 1

HCID 22024599HCID 22024599, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A 5N aqueous sodium hydroxide solution (0.603 mL, 3.0 mmol) was added to a solution of methyl 8-(2,4-dimethylphenyl)-2-ethylimidazo[1,2-b]pyridazine-3-carboxylate (373 mg, 1.20 mmol) in ethanol (15 mL), and the mixture was heated under reflux for 1 hour. 5N hydrochloric acid (0.603 mL) was added thereto under ice-cooling and the solvent was evaporated, to give 8-(2,4-dimethylphenyl)-2-ethylimidazo[1,2-b]pyridazine-3-carboxylic acid as a crude compound.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 1 hour
  3. temperatureunder ice-cooling
  4. customthe solvent was evaporated

Sources & evidence

ORD record
ord-2a6d8a1afc0e40998dc141f77e43efb9
Source dataset
uspto-grants-2006_07
Patent number
US07078405B2

Reaction notes

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