Ethanol → Ethanol water glycerin glycerol monooleate

HRID 1793269Notes

Reaction equation

HRID 1793269 reaction equation
[CH2:1]([OH:3])[CH3:2].[C:4]([O:23][CH2:24][CH:25]([CH2:27][OH:28])[OH:26])(=[O:22])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]/[CH:12]=[CH:13]\[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]>O.OCC(CO)O>[CH2:1]([OH:3])[CH3:2].[OH2:22].[OH:23][CH2:24][CH:25]([CH2:27][OH:28])[OH:26].[C:4]([O:23][CH2:24][CH:25]([CH2:27][OH:28])[OH:26])(=[O:22])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]/[CH:12]=[CH:13]\[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]

Participants

5

Reactant 2

HCID 702EthanolHCID 5283468Glyceryl Monooleate

Product 1

HCID 131716747Ethanol water glycerin glycerol monooleate

Reagents, catalysts & solvents 2

HCID 753GlycerolSolventHCID 962WaterSolvent

Procedure

95% ethanol (USP) was diluted with water (USP), glycerin (USP), and glycerol monooleate (Eastman Chemical, Kingsport NY) to provide a final solution at ethanol/water/glycerin/glycerol monooleate percent ratios of 35/59/5/1, respectively. Oxybutynin free base was then dissolved into the above solution to a concentration of 10 mg/gram. The resultant solution was then gelled with 1% hydroxypropyl cellulose (Aqualon, Wilmington, Del.) to provide a final oxybutynin gel. One to two grams of the above gel is applied topically to approximately 200 cm2 surface area on the chest, torso, and or arms to provide topical administration of oxybutynin.

Sources & evidence

ORD record
ord-f07d33de0b8549108bb55562f9fdb65a
Source dataset
uspto-grants-2006_07
Patent number
US07081251B2

Reaction notes

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