Hydrochloric Acid → HCID 178526420, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1 g (4.4 mmol) 2,3-dihydroxy-6-trifluoromethylquinoxaline in 10 ml concentrated H2SO4 is cooled to 0° C. and 438 mg (4.4 mmol) KNO3 is added. The mixture is stirred at 0° C. for 0.5 h and at 24° C. for 3 h. The reaction mixture is poured into ice-water to give 1.02 g crude product. The crude product is dissolved in 2N NaOH. Addition of 4N HCl to pH 5 gives 0.86 g (72%) 2,3-dihydroxy-6-nitro-7-trifluoromethylquinoxaline. NMR: two singlets (7.5 and 7.8 ppm downfield from TMS).

Provenance & Evidence