Potassium Carbonate → HCID 178435433, compound

HRID 1793285Notes

Reaction equation

HRID 1793285 reaction equation
[OH:1][C:2]1[C:11]([OH:12])=[N:10][C:9]2[C:4](=[CH:5][C:6]([N+:19]([O-:21])=[O:20])=[C:7]([C:13]#[C:14][Si](C)(C)C)[CH:8]=2)[N:3]=1.C(=O)([O-])[O-].[K+].[K+]>CO>[C:13]([C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][C:6]=1[N+:19]([O-:21])=[O:20])[N:3]=[C:2]([OH:1])[C:11]([OH:12])=[N:10]2)#[CH:14]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 178504177HCID 178504177, compound

Product 1

HCID 178435433HCID 178435433, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 300 mg (0.99 mmol) 2,3-dihydroxy-6-trimethylsilylethynyl-7-nitroquinoxaline in 10 ml methanol is added to 200 mg (1.45 mmol) potassium carbonate and then stirred at room temperature for 1 h. The reaction mixture is evaporated in vacuo and 4N hydrochloric acid is added to pH 6. The precipitated product is filtered off and washed with water to give 200 mg (88%) of 6-ethynyl-2,3-dihydroxy-7-nitroquinoxaline. NMR (DMSO-d6): δ 7.7 (1H, s), δ 7.2 (1H, s), δ 4.5 (1H, s).

Workup

  1. customThe reaction mixture is evaporated in vacuo and 4N hydrochloric acid
  2. additionis added to pH 6
  3. filtrationThe precipitated product is filtered off
  4. washwashed with water

Sources & evidence

ORD record
ord-0ece84acd02d486896ae7513d4434d3f
Source dataset
uspto-grants-2006_07
Patent number
US07081346B2

Reaction notes

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