Triphenylphosphine → HCID 22022050, compound

HRID 1793302Notes

Reaction equation

HRID 1793302 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[C:10](=[O:27])[N:11]([CH2:24][CH2:25]O)[N:12]=[C:13]([CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[F:23])[C:14]=2[CH3:15])[CH:6]=[CH:7][CH:8]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[Br:47]NC(=O)CCC(N)=O>ClCCl>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[C:10](=[O:27])[N:11]([CH2:24][CH2:25][Br:47])[N:12]=[C:13]([CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[F:23])[C:14]=2[CH3:15])[CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 11776TriphenylphosphineHCID 9834204N-BromosuccinamideHCID 22022028HCID 22022028, compound

Product 1

HCID 22022050HCID 22022050, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 4-(3-methoxyphenyl)-5-methyl-6-(2-fluorobenzyl)-2-(2-hydroxyethyl)-pyridazin-3-one (from above) and triphenylphospine (570 mg, 22 mmol) in dichloromethane (8 mL) was treated with N-bromosuccinamide (400 mg, 22 mmol) at room temperature for 2 hours. The crude product was used for next step. MS: 431 (MH+).

Sources & evidence

ORD record
ord-111159e019154de4a7d6678f976321db
Source dataset
uspto-grants-2006_07
Patent number
US07081459B2

Reaction notes

Loading…