反应详情

Dimethylformamide (0.25 ml) was added dropwise to a solution of 6-acetoxy-7-methoxy-3,4-dihydro-quinazolin-4-one (13.8 g, 59.0 mmol) in thionyl chloride (150 ml) and the reaction was heated at reflux for 1.5 hours. The reaction was cooled, excess thionyl chloride was removed in vacuo and the residue was azeotroped with toluene (2×50 ml) to remove the last of the thionyl chloride. Drying in vacuo yielded 4-chloro-6-acetoxy-7-methoxyquinazoline hydrochloride (14.7 g, 87% yield) as a beige solid, which was used without further purification:

1. temperaturethe reaction was heated
2. temperatureat reflux for 1.5 hours
3. temperatureThe reaction was cooled
4. customexcess thionyl chloride was removed in vacuo
5. customthe residue was azeotroped with toluene (2×50 ml)
6. customto remove the last of the thionyl chloride
7. customDrying in vacuo