Piconol → HCID 22022154, compound

HRID 1793433Notes

Reaction equation

HRID 1793433 reaction equation
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1.[F:9][C:10]1[CH:11]=[C:12]([N+:17]([O-:19])=[O:18])[CH:13]=[CH:14][C:15]=1F>>[N:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[CH2:2][O:1][C:15]1[CH:14]=[CH:13][C:12]([N+:17]([O-:19])=[O:18])=[CH:11][C:10]=1[F:9]

Participants

3

Reactant 2

HCID 11474PiconolHCID 1230531,2-Difluoro-4-nitrobenzene

Product 1

HCID 22022154HCID 22022154, compoundYield 58%

Procedure

An analogous reaction to that described in example 42b, but starting with 2-(hydroxymethyl)pyridine (3.50 g, 36 mmol) and 3,4-difluoronitrobenzene (5.00 g, 31.4 mmol), yielded 2-((2-pyridyl)methoxy)-5-nitrofluorobenzene (4.50 g, 58% yield) as a yellow solid. d) An analogous reaction to that described in example 42c, but starting with 2-((2-pyridyl)methoxy)-5-nitrofluorobenzene (4.5 g, 18.1 mmol), yielded 3-fluoro-4-((2-pyridyl)methoxy)aniline (1.86 g, 47% yield) as a yellow solid.

Workup

  1. customAn analogous reaction to

Sources & evidence

ORD record
ord-10b4a1e360fd44fd8067583fd1414ad1
Source dataset
uspto-grants-2006_07
Patent number
US07081461B1

Reaction notes

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