Ammonia → HCID 69434253, compound

HRID 1793552Notes

Reaction equation

HRID 1793552 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:10]=[C:11]2[C:16]3=[C:17]([C@@H:19]4[CH2:24][NH:23][CH2:22][CH2:21][C@@H:20]4[N:15]3[CH2:14][CH2:13][CH2:12]2)[CH:18]=1.Br[CH2:26][CH2:27][CH2:28][CH3:29].N>>[CH2:26]([N:23]1[CH2:22][CH2:21][C@@H:20]2[N:15]3[C:16]4[C:11](=[CH:10][C:9]([C:3]5[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=5[Cl:1])=[CH:18][C:17]=4[C@@H:19]2[CH2:24]1)[CH2:12][CH2:13][CH2:14]3)[CH2:27][CH2:28][CH3:29]

Participants

4

Reactant 3

HCID 222AmmoniaHCID 8002Butyl bromideHCID 9975710HCID 9975710, compound

Product 1

HCID 69434253HCID 69434253, compound

Procedure

The title compound was prepared by the method of Example 382 as a yellow oil (21 mg, 61%) from (7aS,11aR)-2-(2,4-dichlorophenyl)-5,6,7a,8,9,10,11,11a-octahydro-4H-pyrido[3′,4′:4,5]pyrrolo[3,2,1-ij]quinoline (30 mg, 0.083 mmol) and 1-bromobutane (23 mg, 0.17 mmol). MS (CI, NH3): 415.1 (base, M+H).

Sources & evidence

ORD record
ord-c59f42d892b249838ff953619909281e
Source dataset
uspto-grants-2006_07
Patent number
US07081455B2

Reaction notes

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